Sarah Grilo was born in 1919 in Buenos Aires, the city where she first studied painting with the Spanish painter Vicente Puig. She lived in France and England and, after obtaining the JS Guggenheim Foundation scholarship in 1962, moved to New York. In 1970 she moved to Spain, where she lived until her death in 2007.
In 1952 she formed the Group of Modern Artists together with Tomás Maldonado, Enio Iommi, José Antonio Fernández Muro and Lidy Prati, among others. The group held exhibitions at the Museum of Modern Art, Rio de Janeiro and the Stedelijk in Amsterdam before its dissolution in 1957.
She individually and collectively exhibited in numerous galleries, museums and institutions in the US, Europe and South America, including: the National Museum of Fine Arts, Buenos Aires (MNBA); Cisneros Fontanals Art Foundation (CIFO), Miami; Stedelijk Art Museum, Amsterdam; Museum of Fine Arts, Caracas; Institute of Contemporary Art, Lima; Latin American Museum of Modern Art, Washington DC; The Nelson Rockefeller Collection, New York; University of Texas Art Museum; Spanish Museum of Contemporary Art, Madrid; Queen Sofia National Art Museum, Madrid.